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 | Acesso ao texto completo restrito à biblioteca da Embrapa Clima Temperado. Para informações adicionais entre em contato com cpact.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Clima Temperado. |
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Data corrente: |
27/12/2023 |
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Data da última atualização: |
27/12/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MELLO, J. E. DE; LUDUVICO, K. P.; SANTOS, A. DOS; TEIXEIRA, F. C.; CARDOSO, J. DE S.; AGUIAR, M. S. S. DE; CUNICO, W.; VIZZOTTO, M.; STEFANELLO, F.; SPANEVELLO, R. |
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Afiliação: |
JULIA EISENHARDT DE MELLO, UNIVERSIDADE FEDERAL DE PELOTAS; KARINA PEREIRA LUDUVICO, UNIVERSIDADE FEDERAL DE PELOTAS; ALESSANDRA DOS SANTOS, UNIVERSIDADE FEDERAL DE PELOTAS; FERNANDA CARDOSO TEIXEIRA, UNIVERSIDADE FEDERAL DE PELOTAS; JULIANE DE SOUZA CARDOSO, UNIVERSIDADE FEDERAL DE PELOTAS; MAYARA SANDRIELLY SOARES DE AGUIAR, UNIVERSIDADE FEDERAL DE PELOTAS; WILSON CUNICO, UNIVERSIDADE FEDERAL DE PELOTAS; MARCIA VIZZOTTO FOSTER, CPACT; FRANCIELI STEFANELLO, UNIVERSIDADE FEDERAL DE PELOTAS; ROSELIA SPANEVELLO, UNIVERSIDADE FEDERAL DE PELOTAS. |
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Título: |
Therapeutic potential of blackberry extract in the preventing memory defcits and neurochemical alterations in the cerebral cortex, hippocampus and cerebellum of a rat model with amnesia. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Metabolic Brain Disease, v. 38, p. 1261–1272, 2023. |
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DOI: |
https://doi.org/10.1007/s11011-023-01175-w |
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Idioma: |
Inglês |
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Conteúdo: |
The blackberry (Rubus sp.) is a popular fruit that has a high concentration of phenolic compounds. Pharmacological investigations have demonstrated the important biological activities of the blackberry extract, such as neuroprotective actions. This study aimed to evaluate the efects of blackberry extract on memory and neurochemical parameters in rats subjected to scopolamine (SCO)-induced amnesia. Male rats were divided into fve groups: I, control (saline); II, SCO; III, SCO +Rubus sp. (100 mg/kg); IV, SCO+Rubus sp. (200 mg/kg); and V, SCO+donepezil (5 mg/kg). Blackberry extract and donepezil were orally administered for 10 days. On day 11, group I received saline, and groups II, III, IV, and V received SCO (1 mg/kg) intraperitoneally after object recognition behavioral training. Twenty-four hours after the training session, animals were subjected to an object recognition test. Finally, the animals were euthanized, and the cerebral cortex, hippocampus, and cerebellum were collected to evaluate the oxidative stress and acetylcholinesterase (AChE) activity. Rubus sp. extract prevented memory impairment induced by SCO in a manner similar to that of donepezil. Additionally, Rubus sp. extract and donepezil prevented the increase in AChE activity induced by SCO in all the evaluated brain structures. SCO induced oxidative damage in the cerebral cortex, hippocampus, and cerebellum, which was prevented by Rubus sp. and donepezil. Our results suggest that the antioxidant and anticholinesterase activities of Rubus sp. are associated with memory improvement; hence, it can potentially be used for the treatment of neurodegenerative diseases. MenosThe blackberry (Rubus sp.) is a popular fruit that has a high concentration of phenolic compounds. Pharmacological investigations have demonstrated the important biological activities of the blackberry extract, such as neuroprotective actions. This study aimed to evaluate the efects of blackberry extract on memory and neurochemical parameters in rats subjected to scopolamine (SCO)-induced amnesia. Male rats were divided into fve groups: I, control (saline); II, SCO; III, SCO +Rubus sp. (100 mg/kg); IV, SCO+Rubus sp. (200 mg/kg); and V, SCO+donepezil (5 mg/kg). Blackberry extract and donepezil were orally administered for 10 days. On day 11, group I received saline, and groups II, III, IV, and V received SCO (1 mg/kg) intraperitoneally after object recognition behavioral training. Twenty-four hours after the training session, animals were subjected to an object recognition test. Finally, the animals were euthanized, and the cerebral cortex, hippocampus, and cerebellum were collected to evaluate the oxidative stress and acetylcholinesterase (AChE) activity. Rubus sp. extract prevented memory impairment induced by SCO in a manner similar to that of donepezil. Additionally, Rubus sp. extract and donepezil prevented the increase in AChE activity induced by SCO in all the evaluated brain structures. SCO induced oxidative damage in the cerebral cortex, hippocampus, and cerebellum, which was prevented by Rubus sp. and donepezil. Our results suggest that the antioxidant and anticholi... Mostrar Tudo |
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Thesagro: |
Amora; Amora Preta; Extrato; Extrato de Fruta. |
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Thesaurus Nal: |
Rubus. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02619naa a2200301 a 4500
001 2160274
005 2023-12-27
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s11011-023-01175-w$2DOI
100 1 $aMELLO, J. E. DE
245 $aTherapeutic potential of blackberry extract in the preventing memory defcits and neurochemical alterations in the cerebral cortex, hippocampus and cerebellum of a rat model with amnesia.$h[electronic resource]
260 $c2023
520 $aThe blackberry (Rubus sp.) is a popular fruit that has a high concentration of phenolic compounds. Pharmacological investigations have demonstrated the important biological activities of the blackberry extract, such as neuroprotective actions. This study aimed to evaluate the efects of blackberry extract on memory and neurochemical parameters in rats subjected to scopolamine (SCO)-induced amnesia. Male rats were divided into fve groups: I, control (saline); II, SCO; III, SCO +Rubus sp. (100 mg/kg); IV, SCO+Rubus sp. (200 mg/kg); and V, SCO+donepezil (5 mg/kg). Blackberry extract and donepezil were orally administered for 10 days. On day 11, group I received saline, and groups II, III, IV, and V received SCO (1 mg/kg) intraperitoneally after object recognition behavioral training. Twenty-four hours after the training session, animals were subjected to an object recognition test. Finally, the animals were euthanized, and the cerebral cortex, hippocampus, and cerebellum were collected to evaluate the oxidative stress and acetylcholinesterase (AChE) activity. Rubus sp. extract prevented memory impairment induced by SCO in a manner similar to that of donepezil. Additionally, Rubus sp. extract and donepezil prevented the increase in AChE activity induced by SCO in all the evaluated brain structures. SCO induced oxidative damage in the cerebral cortex, hippocampus, and cerebellum, which was prevented by Rubus sp. and donepezil. Our results suggest that the antioxidant and anticholinesterase activities of Rubus sp. are associated with memory improvement; hence, it can potentially be used for the treatment of neurodegenerative diseases.
650 $aRubus
650 $aAmora
650 $aAmora Preta
650 $aExtrato
650 $aExtrato de Fruta
700 1 $aLUDUVICO, K. P.
700 1 $aSANTOS, A. DOS
700 1 $aTEIXEIRA, F. C.
700 1 $aCARDOSO, J. DE S.
700 1 $aAGUIAR, M. S. S. DE
700 1 $aCUNICO, W.
700 1 $aVIZZOTTO, M.
700 1 $aSTEFANELLO, F.
700 1 $aSPANEVELLO, R.
773 $tMetabolic Brain Disease$gv. 38, p. 1261–1272, 2023.
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Embrapa Clima Temperado (CPACT) |
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Registro Completo
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Biblioteca(s): |
Embrapa Soja. |
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Data corrente: |
29/06/2005 |
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Data da última atualização: |
22/05/2006 |
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Autoria: |
LAPIED, E.; FRAGOSO, C.; BROWN, G.; LAVELLE, P. |
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Título: |
MACROFAUNA version 2.0 - a database management system for assessing the soil fauna diversity of natural and disturbed ecosystems. |
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Ano de publicação: |
2004 |
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Fonte/Imprenta: |
In: INTERNATIONAL COLLOQUIUM ON SOIL ZOOLOGY AND ECOLOGY, 14., 2004. Mont Saint Aignan. Abstracts. Mont Saint Aignan: Université de Rouen, 2004. p. 44. |
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Idioma: |
Inglês |
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Conteúdo: |
The MACROFAUNA database is the result, in a first time, of a pioneer version written and developed in Dbase IV TM by Carlos Fragoso at the beginning of the 1990's and, in a second time, of a consultation between all participants of the two International Biodiversity Observation Year (IBOY) workshops held in Bondy (France) in June 2000 and december 2001. The major interest of the MACROFAUNA database is that it will constitute a considerable sum of data which can be used as basic tool as for numerous of fundamental questions than for applied researches. Main objectives are : 1- to assess the soil macrofauna biodiversity at different geographic scales, from local to regional. 2 - to assess the influence of land use, biota pertubation or specific environmental factors on soil macrofauna. 3 - to assess the influence of soil macrofauna communities modifications on soil properties and 4 - to research bioindicators associated with specific environmental parameters or soil pertubations. All data are collected on the basis of the sampling pattern as defined by the Tropical Soil Biology and Fertility (TSBF) protocole : a site is represented by a transect or a quadrat and identical soil monolithes are carried out at regular intervals. Each monolithe is divided in regular strata. MACROFAUNA database contains at present data for 843 sites and 7486 samples, distributed over 37 countries through the worl (Europe : 42 sites and 557 samples ; North America : 12 sites and 144 samples ; Central and South America : 460 sites and 4006 samples ; Africa : 216 sites and 1960 samples ; and Asia/Oceania : 113 sites and 819 samples). MACROFAUNA V2.0 was written in Microsoft Access and contains 155 variables distributed among 5 distinct groups: 3 are linked to the different levels of precision of field sampling (sites, soil samples and strata) with 123 environmental and biological variables and the two others, to the taxonomical aspect of the sampled fauna and to the bibliographical references in which results were published. Because of the great number of variables and to make data input and extraction easier, the database was divided in two distinct interfaces: the "data input interface", an interface in wich data are distributed in 5 "one-to-several" related tables corresponding to the 5 variables groups, and the "data extraction interface", in which all data are brought together in the same table. Search and extraction of data can be executed via keywords and an advanced search can be executed by way of a combinaison of keywords with the help of classical Boolean operators. The result of a query appears in tabular form and can be directly exported under numerous formats (txt, rtf, ASCII, Microsoft Excel...). A preliminary result of the data analysis underlines a soil fauna total density significantly higher in the tropical areas compared to temperatures ones because of a great abundance of termites and ants, and a soil fauna total biomass significantly higher in the temperate areas because of a greater abundance of earthworms. MenosThe MACROFAUNA database is the result, in a first time, of a pioneer version written and developed in Dbase IV TM by Carlos Fragoso at the beginning of the 1990's and, in a second time, of a consultation between all participants of the two International Biodiversity Observation Year (IBOY) workshops held in Bondy (France) in June 2000 and december 2001. The major interest of the MACROFAUNA database is that it will constitute a considerable sum of data which can be used as basic tool as for numerous of fundamental questions than for applied researches. Main objectives are : 1- to assess the soil macrofauna biodiversity at different geographic scales, from local to regional. 2 - to assess the influence of land use, biota pertubation or specific environmental factors on soil macrofauna. 3 - to assess the influence of soil macrofauna communities modifications on soil properties and 4 - to research bioindicators associated with specific environmental parameters or soil pertubations. All data are collected on the basis of the sampling pattern as defined by the Tropical Soil Biology and Fertility (TSBF) protocole : a site is represented by a transect or a quadrat and identical soil monolithes are carried out at regular intervals. Each monolithe is divided in regular strata. MACROFAUNA database contains at present data for 843 sites and 7486 samples, distributed over 37 countries through the worl (Europe : 42 sites and 557 samples ; North America : 12 sites and 144 samples ; Central... Mostrar Tudo |
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Palavras-Chave: |
Ecologia do solo. |
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Thesagro: |
Biologia do Solo; Minhoca. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 03732naa a2200193 a 4500
001 1464169
005 2006-05-22
008 2004 bl --- 0-- u #d
100 1 $aLAPIED, E.
245 $aMACROFAUNA version 2.0 - a database management system for assessing the soil fauna diversity of natural and disturbed ecosystems.
260 $c2004
520 $aThe MACROFAUNA database is the result, in a first time, of a pioneer version written and developed in Dbase IV TM by Carlos Fragoso at the beginning of the 1990's and, in a second time, of a consultation between all participants of the two International Biodiversity Observation Year (IBOY) workshops held in Bondy (France) in June 2000 and december 2001. The major interest of the MACROFAUNA database is that it will constitute a considerable sum of data which can be used as basic tool as for numerous of fundamental questions than for applied researches. Main objectives are : 1- to assess the soil macrofauna biodiversity at different geographic scales, from local to regional. 2 - to assess the influence of land use, biota pertubation or specific environmental factors on soil macrofauna. 3 - to assess the influence of soil macrofauna communities modifications on soil properties and 4 - to research bioindicators associated with specific environmental parameters or soil pertubations. All data are collected on the basis of the sampling pattern as defined by the Tropical Soil Biology and Fertility (TSBF) protocole : a site is represented by a transect or a quadrat and identical soil monolithes are carried out at regular intervals. Each monolithe is divided in regular strata. MACROFAUNA database contains at present data for 843 sites and 7486 samples, distributed over 37 countries through the worl (Europe : 42 sites and 557 samples ; North America : 12 sites and 144 samples ; Central and South America : 460 sites and 4006 samples ; Africa : 216 sites and 1960 samples ; and Asia/Oceania : 113 sites and 819 samples). MACROFAUNA V2.0 was written in Microsoft Access and contains 155 variables distributed among 5 distinct groups: 3 are linked to the different levels of precision of field sampling (sites, soil samples and strata) with 123 environmental and biological variables and the two others, to the taxonomical aspect of the sampled fauna and to the bibliographical references in which results were published. Because of the great number of variables and to make data input and extraction easier, the database was divided in two distinct interfaces: the "data input interface", an interface in wich data are distributed in 5 "one-to-several" related tables corresponding to the 5 variables groups, and the "data extraction interface", in which all data are brought together in the same table. Search and extraction of data can be executed via keywords and an advanced search can be executed by way of a combinaison of keywords with the help of classical Boolean operators. The result of a query appears in tabular form and can be directly exported under numerous formats (txt, rtf, ASCII, Microsoft Excel...). A preliminary result of the data analysis underlines a soil fauna total density significantly higher in the tropical areas compared to temperatures ones because of a great abundance of termites and ants, and a soil fauna total biomass significantly higher in the temperate areas because of a greater abundance of earthworms.
650 $aBiologia do Solo
650 $aMinhoca
653 $aEcologia do solo
700 1 $aFRAGOSO, C.
700 1 $aBROWN, G.
700 1 $aLAVELLE, P.
773 $tIn: INTERNATIONAL COLLOQUIUM ON SOIL ZOOLOGY AND ECOLOGY, 14., 2004. Mont Saint Aignan. Abstracts. Mont Saint Aignan: Université de Rouen, 2004. p. 44.
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